does dna methylation plays a critical role in osteoblastic differentiation of mesenchymal stem cells (mscs)?
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Does DNA Methylation Plays a Critical Role in Osteoblastic Differentiation of Mesenchymal Stem Cells (MSCs)?
1 Research Center of Thalassemia and Hemoglobinopathy, Jundishapur University of Medical Sciences, Ahvaz, IR Iran 2 Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran 3 Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands 4 Young Researchers Club, Science and Research Branch, Islamic Azad U...
full textEvaluation of Changes in Global DNA Methylation during Osteoblastic Differentiation of Mesenchymal Stem Cells: A Laboratory Study
Background and Objectives: Control processes in osteoblastic differentiation of mesenchymal stem cells are not yet fully understood. Epigenetic mechanisms, especially the methylation of CpG Islands in the promoter of genes, are considered as one of the most important control mechanisms in stem cell differentiation. In the process of differentiation, it is debated whether only the methylation of...
full textdifferent methylation patterns of runx2, osx, dlx5 and bsp in osteoblastic differentiation of mesenchymal stem cells
objective: runt-related transcription factor 2 (runx2) and osterix (osx) as two specific osteoblast transcription factors and distal-less homeobox 5 (dlx5) as a non-specific one are of paramount importance in regulating osteoblast related genes including osteocalcin, bone sialoprotein (bsp), osteopontin and collagen type iα1. the present study sets out to investigate whether epigenetic regulati...
full textror2 promoter methylation change in osteoblastic differentiation of mesenchymal stem cells
objective: osteoblasts arise from multipotent mesenchymal stem cells (mscs) present in the bone marrow stroma and undergo further differentiation to osteocytes or bone cells. many factors such as proteins present in the wnt signaling pathway affect osteoblast differentiation. ror2 is an orphan tyrosine kinase receptor that acts as a co-receptor in the non-canonical wnt signaling pathway. howeve...
full textNeurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells.
Mutations in the NF1 tumor suppressor gene cause neurofibromatosis type 1, a pandemic autosomal dominant genetic disorder with an incidence of 1:3000. Individuals with NF1 have a variety of malignant and non-malignant manifestations, including skeletal manifestations, such as osteoporosis, scoliosis and short statures. However, the mechanism(s) underlying the osseous manifestations in NF1 are p...
full textتاثیر داروی زولدرونیک اسید در بیان و متیلاسیون ژن BSP در طول تمایز استئوبلاستیک سلولهای بنیادی مزانشیمی
Background and Aim: Bone sialoprotein (BSP) is a specific marker of osteoblastic differentiation. In this research, the effect of Zoledronic Acid on BSP expression and methylation status during osteoblastic differentiation of mesenchymal stem cells (MSCs) was evaluated. Materials and Methods: In this experimental study, MSCs were isolated from human bone marrow. For osteogenic differentiation,...
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Journal title:
iranian red crescent medical journalجلد ۱۵، شماره ۸، صفحات ۷۵۵-۷۵۶
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